Endocrine Abstracts

Introduction: Acute myeloid leukemia infiltrates the CNS in up to 50% of cases. In contrast, the infiltration of the pituitary gland by leukemia cells is unusual. To date, AML presenting with central diabetes insipidus (CDI) has been rarely reported. Here, we present a patient with AML (subtype clasification is proceeding) presenting with panhypopituitarism and CDI.Case report: A 37-years-old man, with no significant past medical history, presented to Em...

Background: Hemangiopericytoma (HPC) is a malignant vasculary tumor originate from pericytes around the capillary and venules. İntracranial hemangiopericytomas usually arise from meninges, rarely they locate periventricular, suprasellar or sellar. Because of the malignancy potential, the differential diagnosis is important. A rare case of sellar HPC mimicking non-functional pituitary adenoma will be presented.Case report: A 45 years old woman has a...

Objective: The prevalence of overweight and obesity has been increasing for several decades. Few studies have recently showed functional and morphological changes of the thyroid gland in relation to obesity. The aim of this study was to correlate thyroid nodule size with body mass index (BMI), waist-hip ratio (WHR) and thyroid stimulating hormone (TSH) levels.Methods: A total of 119 patients diagnosed with euthyroidic nodular goiter were included in this...

Introduction: Thyroid papillary carcinomas originate from thyroid follicular epithelia and are the most frequent thyroid differentiated carcinomas. Medullary thyroid carcinomas originate from thyroid parafollicular C cells and %25 are a component of Multiple Endocrine Neoplasia (MEN) syndromes. Co-incidence of the two condition on the same patient is so rare.Case: 78 years old female patient who has had simple goiter for 10 years, was investigated about ...

Introduction: Differentiated thyroid carcinomas (DTC) are originated from thyroid follicular epithelial cells and comprises %90 of all thyroid carcinomas. Researches indicate that sorafenib is more efficacious than other chemotherapeutic agents on metastatic iodide refractory DTCs.Material and methods: In our center, between 2013 and 2015, sorafenib was applied to six patients who had iodide refractory metastatic DTC. Five of the patients were female. Th...

Introduction: Primary squamous cell carcinoma (PSCC) of thyroid is a rare type of thyroid malignancies because thyroid gland lacks squamous epithelium. It is seen in <1% of all thyroid malignancies. During last 30 years only about 90 cases were published. PSCC is an aggressive tumour as well as rare.Case report: We present a 60-year-old female who had been followed up for multiple nodules in thyroid in our outpatient clinic for 2 years. Her serum fre...

Classic thyroid hormone resistance (THR) occurs per every 400 000 live birth. THR should be considered along with TSH-producing adenomas when normal or high levels of TSH not consistent with hyperthyroidism is present. A 45-year-old female patient who was operated three times for multinodulary goitre had been treated with L-thyroxine. Mamillary biopsy had performed after detection of mass localized in right breast by mammography performed during regular follow-u...

Introduction: Primary thyroid lymphomas are rare cancers and account 1–5% of all thyroid cancers and 3% of all extranodal non hodgkin lymphomas (NHLs). We aimed to present cases of thyroid lymphoma encountered in our clinic.Case 1: A 54-year-old female patient admitted with pain and swallow on the cervical region. In ultrasonographic (USG) thyroid examination, it was found that both thyroid lobes were very large with routh parenchyme consis...

Introduction: A diagnosis of subacute thyroiditis (SAT) is readily suspected when patients present with a particular set of typical clinical and laboratory characteristics. We present a patient with atypical SAT who had no neck pain but presented with fever, and weight loss; had thyrotoxicosis with normal 99mTc uptake, and needed higher doses of steroids to resolve.Case report: A 57-year-old man presented with a fever (39  °C) of 2 month-durati...

Introduction: Resistance to thyroid hormone (RTH) is an inherited syndrome characterized by reduced responsiveness of target tissues to thyroid hormone (TH). It is characterized by high serum concentrations of free T4 (Ft4) and usually free T3 (Ft3) accompanied by normal or slightly high serum TSH concentrations. When RTH is suspected, the diagnosis should be confirmed by direct sequencing of the TR-β gene to identify mutations....